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Promethazine
Clinical data
Trade namesPhenergan, many others [1]
AHFS/Drugs.comMonograph
MedlinePlusa682284
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, rectal, IV, IM, topical
ATC codeD04AA10 ( WHO ) R06AD02 ( WHO )
Legal status
Legal statusAU: S3 (Pharmacist only) CA : OTC UK: P (Pharmacy medicines) (POM when injection), US: ℞-only South Africa: S5 IV S2 Oral
Pharmacokinetic data
Bioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability [2]
Protein binding93%
MetabolismLiver glucuronidation and sulfoxidation
Elimination half-life16–19 hours [2] [3]
ExcretionKidney and biliary

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Br J Clin Pharmacol. 1983 Mar; 3 287-93. doi. 365. b01501. ubMed: 849764Cantisani C, Ricci S, Grieco T, Paolino G, Faina V, Silvestri E, Calvieri S: Camphorated promethazine side effects: our international and sodium of the literature.

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Phenergan instruction
Tablets name Phenergan
Phenergan other namesallersoothe, anergan, antiallersin, anvomin, atosil, avomine, closin, diphergan, diprazinum, fargan, farganesse, fenazil, fenazin, fenazine, fenergan, frinova, hiberna, histabil, histaloc, histantil, histazin, histerzin, insomn-eze, lenazine, lergigan, lilly, nufapreg, otosil, pamergan, phenadoz, phenerex, phenerzine, phergan, pipolphen, polfergan, proazamine chloride, procodin, prohist, promacot, promadryl, promargan, promergan, prometazina, promethacon, promethazin, promethazinum, promethegan, promezin, promodin, proneurin, prorex, prothazin, prothazine, prothiazine, prozin, psicosoma, pyrethia, receptozine, romergan, shogan, synvomin, titanox, tixylix, tixylix linctus, v-gan, vegetamin a
Active substancepromethazine
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