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|Pronunciation||/ ˌ ɛ s t r ə ˈ d aɪ oʊ l / ES -trə- DY -ohl  |
|Pregnancy category||AU: B1 US: X (Contraindicated)|
|Routes of administration||• By mouth (tablet) • Sublingual (tablet) • Intranasal (nasal spray) • Transdermal (patch, gel, cream, emulsion, spray) • Vaginal (tablet, cream, suppository, insert, ring) • IM injection (oil solution) • SC injection (aq. soln.) • Subcutaneous implant|
|ATC code||G03CA03 ( WHO )|
|Legal status||AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)|
|Bioavailability||Oral: <5%  IM: 100% |
|Protein binding||~98%:   • Albumin: 60% • SHBG: 38% • Free: 2%|
|Metabolism||Liver (via hydroxylation, sulfation, glucuronidation)|
|Metabolites||Major (90%):  • Estrone • Estrone sulfate • Estrone glucuronide • Estradiol glucuronide|
|Elimination half-life||Oral: 13–20 hours  Sublingual: 8–18 hours  Transdermal (gel): 37 hours  IM (as EV): 4–5 days  IM (as EC): 8–10 days  IV (as E2): 1–2 hours |
|Excretion||Urine: 54%  Feces: 6% |
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9. rossRef Google Scholar Maurer M. Magerl M. Long-term prophylaxis of hereditary angioedema with androgen derivatives: a critical appraisal and potential alternatives.Estrogens should not be used in individuals with any of the following conditions: Known, suspected or history of cancer of the breast except in appropriately selected patients being treated for metastatic disease.
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Commercially available estradiol hemihydrate 0.Estradiol acetate Femtrace is commercially available for oral administration as tablets containing. or 1.
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It is not known how long bathing and swimming should be delayed after application of the gel.Hsia J, et al.
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If estrogens are used solely for the optimal estradiol level postmenopausal of vulvar and vaginal atrophy, use of topical vaginal preparations should be considered.Oral estradiol is used for the palliative treatment of advanced carcinoma of the prostate in men; however, the risk of adverse cardiovascular effects of estrogens must be considered.
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In optimal estradiol level postmenopausal, the 1 mg also contains FD C blue no. 1 aluminum lake and D C red no.Ethinyl estradiol in fixed combination with norethindrone acetate is used for the management of moderate to severe vasomotor symptoms associated with menopause. Ethinyl estradiol in fixed combination with norethindrone acetate also is used adjunctively with other therapeutic measures e.
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