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Los datos de una mujer lactante ma que sildenafilo y su metabolito activo N-desmetil sildenafilo se excretan en la leche materna a niveles muy bajos.

Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
License dataEU  EMA:  by INN, US   FDA: Sildenafil
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth (tablets), IV
ATC codeG04BE03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: P (Pharmacy medicines) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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Sildenafil was shown to potentiate the hypotensive effects of nitrates, and its co-administration with nitric oxide donors or nitrates t caverta 50 mg any form is therefore contraindicated see section 4.t works by expanding the arteries in the penis, so that blood flows into the penis, and constricting the veins leading out, so that more blood flows in and less flows out, leading to a sustained erection. averta does not t caverta 50 mg erectile dysfunction, but it does treat it so that men may enjoy a normal sex life.

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