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In life-threatening situations due to either aerobes or anaerobes these doses may be increased.If leaks are found, discard solution as sterility may be impaired.

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Eartburn, nausea, vomiting, diarrhea, constipation, and abdominal pain reportedly have occurred in patients receiving intravaginal clindamycin. CDAD, including fulminant pseudomembranous colitis, have been clindamycin nicotinamide to the use of intravaginal clindamycin.Some adverse reactions to drugs are side effects.

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Indicated clindamycin nicotinamide cream procedures should be performed in conjunction with antibiotic therapy.Adverse effects have been reported in about 23% of pregnant patients receiving intravaginal clindamycin and have required discontinuance of the drug in about 2% of such patients.

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